Literature melting point range of aspirin. he literature value for the melting point of aspirin is 135°C. Suppose that a sample of 2022-12-09

Literature melting point range of aspirin Rating: 7,5/10 1163 reviews

Aspirin, also known as acetylsalicylic acid, is a commonly used over-the-counter pain reliever and anti-inflammatory medication. Its melting point, the temperature at which it transitions from a solid to a liquid state, is between 136-138°C. This information can be found in various scientific literature sources, such as chemistry textbooks and research articles.

Aspirin was first synthesized by a German chemist in 1897, and it has since become one of the most widely used medications in the world. It is used to relieve pain, reduce inflammation, and lower the risk of heart attack and stroke. In addition to its medicinal uses, aspirin is also used in the production of rubber, plastics, and other industrial products.

The melting point of aspirin is an important physical property that can affect its stability and effectiveness. For example, if aspirin is stored at a temperature above its melting point, it may become less stable and less effective as a medication. On the other hand, if it is stored at a temperature below its melting point, it may become more stable and have a longer shelf life.

In conclusion, the literature melting point range of aspirin is between 136-138°C. This information can be found in various scientific literature sources, and it is an important physical property that can affect the stability and effectiveness of the medication.

Aspirin

literature melting point range of aspirin

Salicylic acid, the main metabolite of aspirin, is an integral part of human and animal metabolism. It produces its anti - inflammatory effects via suppressing the activity of cyclo oxygenase COX , an enzyme which is responsible for the production of pro - inflammatory mediators such as the prostaglandins. It can pass the pain to the brain, regulate body temperature in the hypothalamus and cause inflammation. Displays anticancer effects in some solid tumors. Application of large amounts of the higher concentration of salicylic acid can also result in systemic toxicity. The beaker was swirled continuously for five minutes and then submerged in a warm water bath in the temperature range of 670C-78oC for 15 minutes, where it was swirled occasionally. Human systemic effects by skin contact: ear tinnitus.

Next

Salicylic acid

literature melting point range of aspirin

Reactivity Profile Salicylic acid is a carboxylic acid. When it is combined with sulfur, some believe that a synergistic keratolytic effect is produced. For a commercial enterprise manufacturing aspirin studies such as this one are vital to determine the most efficient processes to synthesize aspirin. The melting points for the acidic and neutral compounds were hence too low, and the melting point for the basic compound was too high. Salicylic acid was also isolated from the herb meadowsweet Filipendula ulmaria, formerly classified as Spiraea ulmaria by German researchers in 1839. The purpose of our experiment was to synthesize acetyl salicylic acid aspirin and then determine the relative purity of the synthesized sample by observing the melting point temperature range. It is easily prepared on a clean surface by spraying a saturated solution of the salt in methanol followed by evaporation.

Next

What is the literature melting point of aspirin?

literature melting point range of aspirin

Derived by reacting a hot solution of sodium phenolate with carbon dioxide and acidifying the sodium salt thus formed. Salicylic acid belongs to a group of phytochemicals which have been shown to have positive effects on human health. The percent yield of our crude and recrystallized aspirin samples was 77. This could be due to environmental conditions which the sample experienced, such as: inadequate stirring, insufficient application of heat and cold or just pure chance. Uses salicylic acid is a beta-hydroxy acid with keratolytic and antiinflammatory activity.

Next

Aspirin Melting Point Analysis

literature melting point range of aspirin

Of the legumes, seeds, nuts, and cereals, only almonds, water chestnuts and peanuts have significant amounts. Sinks and mixes slowly with water. Aspirin is an ester of salicylic acid, while after ingestion it will undergoes hydrolysis which produce salicylic acid and acetic acid. A skin and severe eye irritant. It can be acetylated to the aspirin. Results and Discussion Table 1. Blocks the production of prostaglandins and thromboxanes.

Next

Experimental Synthesis of Aspirin and Melting Point Purity Analysis Donald Yeargin Essay Example

literature melting point range of aspirin

The phenol and sodium hydroxide react to produce phenol sodium, distillation and dehydration, CO2 carboxylation reaction to obtain sodium salicylate, then using sulfuric acid and produce crude product. Salicylic Acid is a beta hydroxy acid that occurs as a natural compound in plants. The purity of both the crude and recrystallized aspirin samples may have been affected by contamination of some combination of water, reactants, or other substances added during this experiment. Methyl salicylate has pleasant aromas of holly, is used for the preparation of perfume and soap flavor. Simple distillation, which is especially useful in the separation of less-volatile substances from volatile substances, such as sugar from water, can be used to separate a liquid-liquid mixture if the boiling points of the component liquids differ by more than 40-50°C.

Next

Synthesis Of Aspirin Essay

literature melting point range of aspirin

The active extract of the bark, called salicin, after the Latin name for the white willow Salix alba , was isolated and named by the German chemist Johann Andreas Buchner in 1826. Vomiting may occur spontaneously if large amounts are swallowed. Experimental Synthesis of Aspirin and Melting Point Purity Analysis Donald Yeargin Abstract The various methods available to synthesize aspirin lead to the need to examine and evaluate production efficiency and purity. It fluoresces in the blue at 420 nm. Common preparations include a 3% and 6% ointment with equal concentration of sulfur; 6% propylene glycol solution Keralyt ; 5% to 20% with equal parts of lactic acid in flexible collodion for warts Duofilm, Occlusal ; in a cream base at any concentration for keratolytic effects; as a 60% ointment for plantar warts; and in a 40% plaster on velvet cloth for the treatment of calluses and warts 40% salicylic acid plaster. The percent yield was determined to be 33.

Next

he literature value for the melting point of aspirin is 135°C. Suppose that a sample of

literature melting point range of aspirin

Pharmacology Aspirin is a nonsteroidal anti-inflammatory drug NSAID. Free crystalline region The actual line of S-L is lower compared with its corresponding theoretical line because of the influence of under cooling and low-melting eutectic. In 1840, the active compound responsible for willow-barks favorable properties was isolated and identified as Salicin Sneader, 2000. A 100% actual yield is not practically possible; but the actual yield of this synthesis was reduced by multiple factors, including: imprecise synthesis techniques and continual loss of materials at each step. Apart from that, we are also required to find the melting point of aspirin. However, the literature melting point range of aspirin is 136. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.

Next

literature melting point range of aspirin

This new derivative of salicylic acid contained the same analgesic, antipyretic, and anti-inflammatory properties of salicylic acid without the same undesired side effects Sneader, 2000. C12H22O11 was the additive that lowered the freezing point the least in the experiment. The actual yield of the crude aspirin was 2. It is perfume material, used for the preparation of methyl salicylate, salicylic acid ethyl ester; food preservatives, its sodium Salt is mostly used, now a number of countries have been banned; methyl salicylate can be used as oral cleaning agents, such as toothpaste flavor. This sample had a median melting point temperature of 129oC. The first is the diazotization reaction in which a diazonium salt is formed from the conversion of primary aromatic amines, such as aniline, to compounds with the nitroso functional group using a nitrous acid, such as HNO2. In pesticide production, salicylic acid is used for the synthesis of organic phosphorus pesticide Isocarbophos, intermediate isopropyl salicylate isofenphos methyl and Rodenticide warfarin, coumatetralyl intermediate 4-hydroxycoumarin.

Next

literature melting point range of aspirin

The melting point temperature ranges were 126oC-132oC and 129oC-134oC for the crude and recrystallized aspirin samples, respectively. The middle dose of aspirin 0. It is sometimes used …show more content… If the substance melts over a very narrow range, it is assumed that the substance is relatively pure. It helps dissolve the top layer of stratum corneum cells, improving the look and feel of the skin. Nature, 456 7221 , xii. It is like a reset button and sets an addicts neurotransmitter function back to how it was before they were an addict.

Next